A 28-year-old woman with nephrotic syndrome develops generalized edema and ascites. Which sequence best explains the pathophysiology of edema in this condition?
A
Proteinuria → sodium loss → hypovolemia → edema
B
Proteinuria → hypoalbuminemia → reduced oncotic pressure → interstitial fluid accumulation
C
Proteinuria → increased capillary permeability → lymphatic failure
D
Proteinuria → hypertension → venous obstruction